Mapping of Th1-Cell Epitope Regions ofMycobacterium tuberculosisProtein MPT64 (Rv1980c) Using Synthetic Peptides and T-Cell Lines fromM. tuberculosis-Infected Healthy Humans
نویسندگان
چکیده
منابع مشابه
Mapping of Th1-cell epitope regions of Mycobacterium tuberculosis protein MPT64 (Rv1980c) using synthetic peptides and T-cell lines from M. tuberculosis-infected healthy humans.
OBJECTIVE To identify T helper 1 (Th1)-cell stimulating and HLA-promiscuous peptides of MPT64 (Rv1980c), a major secreted antigen of Mycobacterium tuberculosis. MATERIALS AND METHODS Peripheral blood mononuclear cells (PBMCs) were obtained from 35 healthy subjects and typed for HLA-DR molecules using genomic methods. To identify subjects infected with M. tuberculosis, PBMCs were tested in ant...
متن کاملشناسایی اپی توپهای سلولهای CD4+ T در پروتئین ترشحی MPB51 مایکوباکتریوم توبرکلوزیس در موشهای C57BL/6
Introduction & Objective: Both CD4+ type 1 helper (Th1) cells and CD8+ T cells play effective roles in protection against Mycobacterium tuberculosis infection. DNA vaccine encoding MPB51 can induce Th1-type immune responses and protective immunity upon challenge with M.tuberculosis. This study address to identify T-cell immunodominant epitopes on MPB51 in C57BL/6 mice. Materials & Methods : ...
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ژورنال
عنوان ژورنال: Medical Principles and Practice
سال: 2010
ISSN: 1423-0151,1011-7571
DOI: 10.1159/000273073